Structure of PDB 6yw2 Chain A

Receptor sequence
>6yw2A (length=209) Species: 9606 (Homo sapiens) [Search protein sequence]
TKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGK
FTDGIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRT
KAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIF
PEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADER
ARAKVKYLT
3D structure
PDB6yw2 Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2.
ChainA
Resolution2.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.29: hypoxia-inducible factor-proline dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K186 P187 L188 Y197 P200 C201 K204 H205 V209 V210 D211 D212 F213 K2 P3 L4 Y13 P16 C17 K20 H21 V25 V26 D27 D28 F29
BS02 MN A H313 D315 H374 H117 D119 H178
BS03 UN9 A D254 M299 Y303 Y310 H313 Y329 L343 H374 V376 R383 D58 M103 Y107 Y114 H117 Y133 L147 H178 V180 R187 BindingDB: IC50=300nM,EC50=79000nM,Kd=80nM
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

View graph for
Molecular Function
External links
PDB RCSB:6yw2, PDBe:6yw2, PDBj:6yw2
PDBsum6yw2
PubMed33319810
UniProtQ9GZT9|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

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