Structure of PDB 6yw1 Chain A

Receptor sequence
>6yw1A (length=209) Species: 9606 (Homo sapiens) [Search protein sequence]
KPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKF
TDGQDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGR
TKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRI
FPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADE
RARAKVKYL
3D structure
PDB6yw1 Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2.
ChainA
Resolution1.46 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.29: hypoxia-inducible factor-proline dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K186 P187 L188 A190 Y197 P200 C201 K204 H205 I207 V209 V210 D211 D212 F213 K1 P2 L3 A5 Y12 P15 C16 K19 H20 I22 V24 V25 D26 D27 F28
BS02 MN A H313 D315 H374 H118 D120 H179
BS03 AKG A Y310 H313 Y329 H374 V376 R383 Y115 H118 Y134 H179 V181 R188
BS04 BCT A R312 P373 R117 P178
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

View graph for
Molecular Function
External links
PDB RCSB:6yw1, PDBe:6yw1, PDBj:6yw1
PDBsum6yw1
PubMed33319810
UniProtQ9GZT9|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

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