Structure of PDB 6yvx Chain A

Receptor sequence
>6yvxA (length=225) Species: 9606 (Homo sapiens) [Search protein sequence]
NGQTLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTG
KFTDGQLVSQDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNG
KLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWD
AKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYA
ITVWYFDADERARAKVKYLTGRVEL
3D structure
PDB6yvx Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.29: hypoxia-inducible factor-proline dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H313 D315 H374 H128 D130 H189
BS02 2JP A Y310 H313 D315 I327 Y329 H374 R383 Y125 H128 D130 I142 Y144 H189 R198
BS03 BCT A R312 P373 R127 P188
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

View graph for
Molecular Function
External links
PDB RCSB:6yvx, PDBe:6yvx, PDBj:6yvx
PDBsum6yvx
PubMed33319810
UniProtQ9GZT9|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

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