Structure of PDB 6yup Chain A

Receptor sequence
>6yupA (length=594) Species: 9606 (Homo sapiens) [Search protein sequence]
LTVASVLVLIAATIAIIALSPKCLDWWQEGPMYQIYPRSFKDSNKDGNGD
LKGIQDKLDYITALNIKTVWITSFYKSSLKDFRYGVEDFREVDPIFGTME
DFENLVAAIHDKGLKLIIDFIPNHTSDKHIWFQLSRTRTGKYTDYYIWHD
CTHENGKTIPPNNWLSVYGNSSWHFDEVRNQCYFHQFMKEQPDLNFRNPD
VQEEIKEILRFWLTKGVDGFSLDAVKFLLEAKHLRDEIQVNKTQIPDTVT
QYSELYHDFTTTQVGMHDIVRSFRQTMDQYSTEPGRYRFMGTEAYAESID
RTVMYYGLPFIQEADFPFNNYLSMLDTVSGNSVYEVITSWMENMPEGKWP
NWMIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVA
ANLNESYDINTLRSKSPMQWDNSSNAGFSEASNTWLPTNSDYHTVNVDVQ
KTQPRSALKLYQDLSLLHANELLLNRGWFCHLRNDSHYVVYTRELDGIDR
IFIVVLNFGESTLLNLHNMISGLPAKMRIRLSTNSADKGSKVDTSGIFLD
KGEGLIFEHNTKNLLHRQTAFRDRCFVSNRACYSSVLNILYTSC
3D structure
PDB6yup Structural basis for amino acid exchange by a human heteromeric amino acid transporter.
ChainA
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D210 S312 D314 E384 P448 D449
Catalytic site (residue number reindexed from 1) D119 S221 D223 E293 P357 D358
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A N214 D284 F318 L319 E321 N123 D193 F227 L228 E230
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015171 amino acid transmembrane transporter activity
GO:0015174 basic amino acid transmembrane transporter activity
GO:0015184 L-cystine transmembrane transporter activity
GO:0044877 protein-containing complex binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006865 amino acid transport
GO:0010467 gene expression
GO:0015802 basic amino acid transport
GO:0015810 aspartate transmembrane transport
GO:0015811 L-cystine transport
GO:0015813 L-glutamate transmembrane transport
GO:1990822 basic amino acid transmembrane transport
Cellular Component
GO:0005774 vacuolar membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0031526 brush border membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6yup, PDBe:6yup, PDBj:6yup
PDBsum6yup
PubMed32817565
UniProtQ07837|SLC31_HUMAN Amino acid transporter heavy chain SLC3A1 (Gene Name=SLC3A1)

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