Structure of PDB 6yty Chain A

Receptor sequence
>6ytyA (length=353) Species: 9606 (Homo sapiens) [Search protein sequence]
QSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDH
ARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWF
NFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHE
NQLTHTDLKPENILFVNSEFETLYNEHCEEKSVKNTSIRVVDFGSATFDH
EHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHE
NREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENC
KPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPE
ERS
3D structure
PDB6yty DFG-1 Residue Controls Inhibitor Binding Mode and Affinity, Providing a Basis for Rational Design of Kinase Inhibitor Selectivity.
ChainA
Resolution1.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.12.1: dual-specificity kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EAE A A184 K186 F236 L238 L239 L290 D320 A58 K60 F110 L112 L113 L164 D192 BindingDB: Kd=3000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6yty, PDBe:6yty, PDBj:6yty
PDBsum6yty
PubMed32787076
UniProtP49761|CLK3_HUMAN Dual specificity protein kinase CLK3 (Gene Name=CLK3)

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