Structure of PDB 6yti Chain A

Receptor sequence
>6ytiA (length=329) Species: 9606 (Homo sapiens) [Search protein sequence]
ICQSGDVLSARYEIVDLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYC
EAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYD
FIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSD
YTEAYNPRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILA
LGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMI
QKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDL
IQKMLEYDPAKRITLREALKHPFFDLLKK
3D structure
PDB6yti DFG-1 Residue Controls Inhibitor Binding Mode and Affinity, Providing a Basis for Rational Design of Kinase Inhibitor Selectivity.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D288 K290 N293 D325 T342
Catalytic site (residue number reindexed from 1) D138 K140 N143 D172 T189
Enzyme Commision number 2.7.12.1: dual-specificity kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7A7 A F172 A189 K191 F241 L244 S247 D250 E292 L295 V324 F22 A39 K41 F91 L94 S97 D100 E142 L145 V171
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6yti, PDBe:6yti, PDBj:6yti
PDBsum6yti
PubMed32787076
UniProtP49759|CLK1_HUMAN Dual specificity protein kinase CLK1 (Gene Name=CLK1)

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