Structure of PDB 6ysy Chain A

Receptor sequence
>6ysyA (length=767) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
KDADMAIFGEAAPYLRKSEKERIEAQNKPFDAKSSVFVADPKESFVKATV
QSREGGKVTAKTEAGATVTVKEDQVFPMNPPKYDKIEDMAMMTHLHEPAV
LYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVTAYRGKKRQEAP
PHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIMQG
TLEDQIISANPLLEAFANAKTVRNDNSSRFGKFIRIHFGTTGKLASADIE
TYLLEKSRVTFQLKAERSYHIFYQIMSNKKPDLIEMLLITTNPYDYAFVS
QGEITVPSIDDQEELMATDSAIDILGFTSDERVSIYKLTGAVMHYGNMKF
KQKQREEQAEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKG
QTVQQVYNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAG
FEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFG
MDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQ
KPKPEAHFSLVHYAGTVDYNITGWLDKNKDPLNETVVGLYQKSAMKTLAF
LFTSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELV
LHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQFIDSK
KASEKLLGSIDVDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQLITRTQ
AMCRGFLARVEYKKMVE
3D structure
PDB6ysy Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness.
ChainA
Resolution3.246 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A N127 P128 X130 W131 G182 G184 K185 T186 V187 N241 N125 P126 X128 W129 G180 G182 K183 T184 V185 N224
BS02 MG A T186 S245 T184 S228
BS03 PJT A F247 G248 Y269 L270 I465 A466 L476 C480 V650 F654 L658 F230 G231 Y252 L253 I448 A449 L459 C463 V608 F612 L616
Gene Ontology
Molecular Function
GO:0000146 microfilament motor activity
GO:0003774 cytoskeletal motor activity
GO:0003779 actin binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0051015 actin filament binding
Biological Process
GO:0006936 muscle contraction
Cellular Component
GO:0005737 cytoplasm
GO:0016459 myosin complex
GO:0016460 myosin II complex
GO:0030016 myofibril
GO:0032982 myosin filament
GO:0043232 intracellular non-membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ysy, PDBe:6ysy, PDBj:6ysy
PDBsum6ysy
PubMed33035452
UniProtQ28641|MYH4_RABIT Myosin-4 (Gene Name=MYH4)

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