Structure of PDB 6yso Chain A

Receptor sequence
>6ysoA (length=982) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
MEAAHSKSTEECLAYFGVSETTGLTPDQVKRHLEKYGHNELPAEEGKSLW
ELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILIA
NAIVGVWQERNAENAIEALKEYEPEMGKVYRADRKSVQRIKARDIVPGDI
VEVAVGDKVPADIRILSIKSTTLRVDQSILTGESVSVIKHTEPVPDPRAV
NQDKKNMLFSGTNIAAGKALGIVATTGVSTEIGKIRDQMAATEQDKTPLQ
QKLDEFGEQLSKVISLICVAVWLINIGHWIRGAIYYFKIAVALAVAAIPE
GLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTN
QMSVCKMFIIDKVDGDFCSLNEFSITGSTYAPEGEVLKNDKPIRSGQFDG
LVELATICALCNDSSLDFNETKGVYEKVGEATETALTTLVEKMNVFNTEV
RNLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSSRAAVG
NKMFVKGAPEGVIDRCNYVRVGTTRVPMTGPVKEKILSVIKEWGTGRDTL
RCLALATRDTPPKREEMVLDDSSRFMEYETDLTFVGVVGMLDPPRKEVMG
SIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVADRAYTGREFD
DLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAP
ALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQ
FIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGF
NPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATVGAAAWWFMYA
EDGPGVTYHQLTHFMQCHPHFEGLDCEIFEAPEPMTMALSVLVTIEMCNA
LNSLSENQSLMRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLKAL
DLTQWLMVLKISLPVIGLDEILKFIARNYLEG
3D structure
PDB6yso Experimental phasing with vanadium and application to nucleotide-binding membrane proteins.
ChainA
Resolution3.13 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.2.2.10: P-type Ca(2+) transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 128 A V185 S186 K205 T441 F487 M494 K515 A517 R560 N628 V185 S186 K205 T432 F478 M485 K506 A508 R551 N619
BS02 VN4 A G182 D351 K352 T353 T625 G626 K684 G182 D342 K343 T344 T616 G617 K675
BS03 MG A D351 T353 D703 D342 T344 D694
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005388 P-type calcium transporter activity
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
Biological Process
GO:0006816 calcium ion transport
GO:0006874 intracellular calcium ion homeostasis
GO:0031448 positive regulation of fast-twitch skeletal muscle fiber contraction
GO:0070588 calcium ion transmembrane transport
GO:0106134 positive regulation of cardiac muscle cell contraction
GO:1901896 positive regulation of ATPase-coupled calcium transmembrane transporter activity
GO:1902082 positive regulation of calcium ion import into sarcoplasmic reticulum
GO:1990036 calcium ion import into sarcoplasmic reticulum
Cellular Component
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0033017 sarcoplasmic reticulum membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6yso, PDBe:6yso, PDBj:6yso
PDBsum6yso
PubMed33209320
UniProtP04191|AT2A1_RABIT Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (Gene Name=ATP2A1)

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