Structure of PDB 6yqp Chain A

Receptor sequence
>6yqpA (length=126) Species: 9606 (Homo sapiens) [Search protein sequence]
MNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKL
NLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKP
GDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB6yqp Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma.
ChainA
Resolution1.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P8N A W81 P82 L92 L94 N140 D145 I146 M149 W39 P40 L50 L52 N98 D103 I104 M107 MOAD: ic50=1.35uM
External links
PDB RCSB:6yqp, PDBe:6yqp, PDBj:6yqp
PDBsum6yqp
PubMed32599645
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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