Structure of PDB 6yqn Chain A

Receptor sequence
>6yqnA (length=125) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPT
3D structure
PDB6yqn Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma.
ChainA
Resolution1.05 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P8T A W81 P82 F83 L92 L94 N140 I146 M149 W40 P41 F42 L51 L53 N99 I105 M108 MOAD: ic50=0.72uM
External links
PDB RCSB:6yqn, PDBe:6yqn, PDBj:6yqn
PDBsum6yqn
PubMed32599645
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

[Back to BioLiP]