Structure of PDB 6yq1 Chain A

Receptor sequence
>6yq1A (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
YEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSV
REKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVR
KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGD
FGLSRYMEDSTYYKAKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILM
HGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRP
RFTELKAQLSTILEEEKAQ
3D structure
PDB6yq1 Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2.
ChainA
Resolution1.784 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D546 A548 R550 N551 D564
Catalytic site (residue number reindexed from 1) D132 A134 R136 N137 D150
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P7N A R426 I428 E430 A452 L501 C502 G505 L553 D564 L567 S568 R12 I14 E16 A38 L87 C88 G91 L139 D150 L153 S154
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6yq1, PDBe:6yq1, PDBj:6yq1
PDBsum6yq1
PubMed33497606
UniProtQ05397|FAK1_HUMAN Focal adhesion kinase 1 (Gene Name=PTK2)

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