Structure of PDB 6yoj Chain A

Receptor sequence
>6yojA (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
DYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDS
VREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQV
RKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLG
DFGLSRLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVK
NNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLS
TILEEEKAQ
3D structure
PDB6yoj Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2.
ChainA
Resolution1.361 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D546 A548 R550 N551 D564
Catalytic site (residue number reindexed from 1) D133 A135 R137 N138 D151
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P4N A R426 I428 V436 A452 E500 L501 C502 G505 E506 N551 L553 G563 D564 L567 S568 R13 I15 V23 A39 E87 L88 C89 G92 E93 N138 L140 G150 D151 L154 S155 BindingDB: IC50=4.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6yoj, PDBe:6yoj, PDBj:6yoj
PDBsum6yoj
PubMed33497606
UniProtQ05397|FAK1_HUMAN Focal adhesion kinase 1 (Gene Name=PTK2)

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