Structure of PDB 6ymv Chain A

Receptor sequence
>6ymvA (length=887) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
INFFEIYNSLPTLEEKKAFESALNIFNQDRQKVLENRATEAARERWKHDF
EEAKARGDISIEKNLNVKLWKWYNEMLPLVKEEINHCRSLLSEKLSDKKG
LNKVDTNRLGYGPYLTLIDPGKMCVITILELLKLNSTGGVIEGMRTARAV
ISVGKAIEMEFRSEQVLKSESQAKILWPQSIRARIGSVLISMLIQVAKVS
VQGVDPVTKAKVHGEAPAFAHGYQYHNGSKLGVLKIHKTLIRQLNGERLI
ASVQPQLLPMLVEPKPWVNWRSGGYHYTQSTLLRTKDSPEQVAYLKAASD
NGDIDRVYDGLNVLGRTPWTVNRKVFDVVSQVWNKGEGFLDIPGAQDEMV
LPPAPPKNSDPSILRAWKLQVKTIANKFSSDRSNRCDTNYKLEIARAFLG
EKLYFPHNLDFRGRAYPLSPHFNHLGNDMSRGLLIFWHGKKLGPSGLKWL
KIHLSNLFGFDKLPLKDRVAFTESHLQDIKDSAENPLTGDRWWTTADKPW
QALATCFELNEVMKMDNPEEFISHQPVHQDGTCNGLQHYAALGGDVEGAT
QVNLVPSDKPQDVYAHVARLVQKRLEIAAEKGDENAKILKDKITRKVVKQ
TVMTNVYGFSKYLTKHVFSAIRELFHSAHLIQDWLGESAKRISKSIRLDV
DEKSFKNGNKPDFMSSVIWTTPLGLPIVQPYREESKKQVETNLQTVFISD
PFAVNPVNARRQKAGLPPNFIHSLDASHMLLSAAECGKQGLDFASVHDSY
WTHASDIDTMNVVLREQFIKLHEVDLVLRLKEEFDQRYKNYVKIGKLKRS
TDLAQKIIRIRKDLSRKLGRSTTLADEIYFEKKRQELLNEDITDLDALEL
ENGNSGMSVLLPLRLPEIPPKGDFDVTVLRNSQYFFS
3D structure
PDB6ymv Cryo-EM Structures Reveal Transcription Initiation Steps by Yeast Mitochondrial RNA Polymerase.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A Y640 G643 R780 Y225 G228 R365
BS02 dna A Y638 S644 K645 L646 G647 Q1129 Q1135 T1136 V1137 F1138 R1151 Y223 S229 K230 L231 G232 Q688 Q694 T695 V696 F697 R710
Gene Ontology
Molecular Function
GO:0001018 mitochondrial promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003896 DNA primase activity
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0000002 mitochondrial genome maintenance
GO:0006269 DNA replication, synthesis of primer
GO:0006351 DNA-templated transcription
GO:0006390 mitochondrial transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0034245 mitochondrial DNA-directed RNA polymerase complex
GO:0042645 mitochondrial nucleoid
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ymv, PDBe:6ymv, PDBj:6ymv
PDBsum6ymv
PubMed33278362
UniProtP13433|RPOM_YEAST DNA-directed RNA polymerase, mitochondrial (Gene Name=RPO41)

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