Structure of PDB 6yky Chain A

Receptor sequence
>6ykyA (length=281) Species: 9606 (Homo sapiens) [Search protein sequence]
SRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIK
IIRRLDHDNIVKVFEILGPSGSQSVYIVQEYMETDLANVLEQGPLLEEHA
RLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIML
SEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHEL
EQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISRE
AVDFLEQILTFSPMDRLTAEEALSHPYMSIY
3D structure
PDB6yky Biochemical, cellular and structural characterization of novel and selective ERK3 inhibitors.
ChainA
Resolution2.52 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D152 K154 N157 D171 T194
Catalytic site (residue number reindexed from 1) D123 K125 N128 D142 T156
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OWQ A L26 C28 V34 A47 E109 M111 E112 T113 F159 L9 C11 V17 A30 E80 M82 E83 T84 F130
BS02 OWQ A A235 E239 A197 E201
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6yky, PDBe:6yky, PDBj:6yky
PDBsum6yky
PubMed32927028
UniProtQ16659|MK06_HUMAN Mitogen-activated protein kinase 6 (Gene Name=MAPK6)

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