Structure of PDB 6yk2 Chain A

Receptor sequence
>6yk2A (length=262) Species: 10116 (Rattus norvegicus) [Search protein sequence]
GANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFK
YKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVI
DFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRS
KIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYI
EQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKL
KNKWWYDKGECG
3D structure
PDB6yk2 Ionotropic Glutamate Receptor GluA2 in Complex with Bicyclic Pyrimidinedione-Based Compounds: When Small Compound Modifications Have Distinct Effects on Binding Interactions.
ChainA
Resolution1.612 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CGW A E13 Y61 P89 L90 T91 R96 L138 G141 S142 T143 L192 E193 M196 E13 Y61 P89 L90 T91 R96 L138 G141 S142 T143 L192 E193 M196 MOAD: Ki=0.762uM
BindingDB: Ki=80nM,EC50=12600nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:6yk2, PDBe:6yk2, PDBj:6yk2
PDBsum6yk2
PubMed32437601
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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