Structure of PDB 6yjm Chain A

Receptor sequence
>6yjmA (length=217) Species: 9606 (Homo sapiens) [Search protein sequence]
SRARQVELLLVADASMARKYGRGLQHYLLTLASIANRLYSHASIENHIRL
AVVKVVVLGKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFT
REDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLL
GLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDD
GHGNCLLDLPRKQILVP
3D structure
PDB6yjm Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H410 H414 H420 H144 H148 H154
BS02 CA A E270 D353 D360 C471 D474 E7 D87 D94 C205 D208
BS03 CA A E270 D353 D474 E7 D87 D208
BS04 CA A D369 L370 C376 T378 E398 D103 L104 C110 T112 E132
BS05 OU5 A T378 G380 H403 F406 T407 H410 E411 H420 S440 S441 L443 T112 G114 H137 F140 T141 H144 E145 H154 S174 S175 L177 BindingDB: IC50=20.0nM
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6yjm, PDBe:6yjm, PDBj:6yjm
PDBsum6yjm
PubMed33719441
UniProtQ9UNA0|ATS5_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 5 (Gene Name=ADAMTS5)

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