Structure of PDB 6yid Chain A

Receptor sequence
>6yidA (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
SMEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKS
QILLGKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQA
KGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANSGIRIK
IADFGFARYLHSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQ
ANSPQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAF
FSHPFLEQG
3D structure
PDB6yid Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer.
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D131 K133 Q135 N136 D158
Catalytic site (residue number reindexed from 1) D132 K134 Q136 N137 D153
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EDJ A V15 V23 A37 M85 C88 G91 L138 V16 V24 A38 M86 C89 G92 L139 BindingDB: IC50=711nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0010506 regulation of autophagy

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Molecular Function
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Biological Process
External links
PDB RCSB:6yid, PDBe:6yid, PDBj:6yid
PDBsum6yid
PubMed33200929
UniProtQ8IYT8|ULK2_HUMAN Serine/threonine-protein kinase ULK2 (Gene Name=ULK2)

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