Structure of PDB 6yhr Chain A

Receptor sequence
>6yhrA (length=541) Species: 9606 (Homo sapiens) [Search protein sequence]
LWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGK
SLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENV
LTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWG
HDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITC
TGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMT
QQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMG
INKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNR
HLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASL
GIMGTEKCCDNCRSRLDHCYSMDTSWDFGPQAFKLLSAVDILGEKFGIGL
PILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEV
SRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPK
3D structure
PDB6yhr Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
5.6.2.4: DNA 3'-5' helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A H546 S548 Q553 G574 G576 K577 R857 H19 S21 Q26 G47 G49 K50 R330
BS02 ZN A C908 C935 C936 C939 C381 C408 C409 C412
BS03 ZN A H558 E563 H31 E36
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination

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Molecular Function
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Biological Process
External links
PDB RCSB:6yhr, PDBe:6yhr, PDBj:6yhr
PDBsum6yhr
PubMed33199508
UniProtQ14191|WRN_HUMAN Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (Gene Name=WRN)

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