Structure of PDB 6ydz Chain A

Receptor sequence
>6ydzA (length=176) Species: 9606 (Homo sapiens) [Search protein sequence]
NVAHGLAWSYYIGYLRLILPELQARIRTYNQHYGAVSQRLYILLPLDCGV
PDNLSMADPNIRFLDKLPQQTGDRAGIKDRVYSNSIYELLENGQRAGTCV
LEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNN
CRLIAYQEPSSFSLSQEVLRHLRQEE
3D structure
PDB6ydz Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4BW A S162 Y167 R238 Y240 T263 S9 Y14 R80 Y82 T105 BindingDB: EC50=120nM,Kd=1040nM
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:6ydz, PDBe:6ydz, PDBj:6ydz
PDBsum6ydz
PubMed33616279
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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