Structure of PDB 6ydx Chain A

Receptor sequence
>6ydxA (length=856) Species: 9606 (Homo sapiens) [Search protein sequence]
NGKLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWN
IILHSTGHNISRVTFMSAVSSQEKQAEILEYAYHGQIAIVAPEALLAGHN
YTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCF
DEPAFKATFIIKIIRDEQYTALSNMPKKSSGLVQDEFSESVKMSTYLVAF
IVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQ
YPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKI
IAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYEDF
LDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKT
YLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQTLDVKRMMKTWT
LQKGFPLVTVQKKGKELFIQQERFFLYLWHIPLSYVTEGRNYSKYQSVSL
LDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVL
SDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTD
LIYNLLEKLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSAL
LEFACTHNLGNCSTTAMKLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKG
WSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGDNFRTQK
LSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYL
FSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTW
WLRTET
3D structure
PDB6ydx Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor.
ChainA
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E431 H464 E465 H468 E487 E541 Y549
Catalytic site (residue number reindexed from 1) E270 H303 E304 H307 E326 E380 Y388
Enzyme Commision number 3.4.11.3: cystinyl aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ONN A G428 A429 E431 I461 H464 E465 E487 E494 D545 Y549 Y961 G267 A268 E270 I300 H303 E304 E326 E333 D384 Y388 Y788 BindingDB: Ki=3.3nM
BS02 ZN A H464 H468 E487 H303 H307 E326
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6ydx, PDBe:6ydx, PDBj:6ydx
PDBsum6ydx
PubMed32676150
UniProtQ9UIQ6|LCAP_HUMAN Leucyl-cystinyl aminopeptidase (Gene Name=LNPEP)

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