Structure of PDB 6yd9 Chain A

Receptor sequence
>6yd9A (length=198) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
SYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALA
GHCKEIIVTIHADNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLHGVGV
SVVNALSQKLELVIQREGKIHRQIYEHGVPQAPLAVTGETEKTGTMVRFW
PSLETFTNVTEFEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHY
3D structure
PDB6yd9 Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ON2 A N46 E50 D73 R76 G77 I78 P79 R136 T165 N43 E47 D70 R73 G74 I75 P76 R116 T145 MOAD: ic50=110nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:6yd9, PDBe:6yd9, PDBj:6yd9
PDBsum6yd9
PubMed33329764
UniProtP0AES6|GYRB_ECOLI DNA gyrase subunit B (Gene Name=gyrB)

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