Structure of PDB 6ycd Chain A

Receptor sequence
>6ycdA (length=215) Species: 4615 (Ananas comosus) [Search protein sequence]
VPQSIDWRDSGAVTSVKNQGRCGSCWAFASIATVESIYKIKRGNLVSLSE
QQVLDCAVSYGCKGGWINKAYSFIISNKGVASAAIYPYKAAKGTCKTNGV
PNSAYITRYTYVQRNNERNMMYAVSNQPIAAALDASGNFQHYKRGVFTGP
CGTRLNHAIVIIGYGQDSSGKKFWIVRNSWGAGWGEGGYIRLARDVSSSF
GLCGIAMDPLYPTLQ
3D structure
PDB6ycd Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity.
ChainA
Resolution1.35 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q19 C25 H157 N178
Catalytic site (residue number reindexed from 1) Q19 C25 H157 N178
Enzyme Commision number 3.4.22.31: ananain.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TCK A Q19 G23 C25 K63 A135 S136 N156 H157 W180 Q19 G23 C25 K63 A135 S136 N156 H157 W180
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6ycd, PDBe:6ycd, PDBj:6ycd
PDBsum6ycd
PubMed33177555
UniProtP80884|ANAN_ANACO Ananain (Gene Name=AN1)

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