Structure of PDB 6yca Chain A

Receptor sequence
>6ycaA (length=390) Species: 36809 (Mycobacteroides abscessus) [Search protein sequence]
TDIRFLQSRAEHERAFTVFWRAMVGLPALVAADELLELGRYLGAFVQGEL
IGGADSYTSWLTVPGGSRVPHAAVTHIGVLPTHTRRGILTALVTRQLTDI
AGRGEIVASLRASEAVIYRRFGYGIATSSATYRIQRRRAAPLRPIDTGAI
ALLDAAASPEGLAAIYERAAWTGSVARPPQWWRLHELFDAADPVKPYVVT
HPDGYVRYRPQDTAEWFSSSARTISVDDLVAHSDEAYRALVGHLLDLDLV
DVIELGPRPIDDPLPHLVTDPRAVAVAGIRDETWLRLVDVEAALAARTYT
DGAPVVIEVQDTLLPHNAARFSVSSDKVRRTQHTPDISVDVAALGSVYLG
GNTWTRLERAGLVSAQSPGAIRAADALFSTGTQPFAGTNF
3D structure
PDB6yca Structural analysis of the N-acetyltransferase Eis1 from Mycobacterium abscessus reveals the molecular determinants of its incapacity to modify aminoglycosides.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACO A A45 M46 I102 V104 T109 R110 G112 L114 T115 S138 V141 Y143 R145 A22 M23 I77 V79 T84 R85 G87 L89 T90 S113 V116 Y118 R120
Gene Ontology
Molecular Function
GO:0008080 N-acetyltransferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0034069 aminoglycoside N-acetyltransferase activity
Biological Process
GO:0030649 aminoglycoside antibiotic catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0044161 host cell cytoplasmic vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6yca, PDBe:6yca, PDBj:6yca
PDBsum6yca
PubMed32860271
UniProtA0A418LDP6

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