Structure of PDB 6yb8 Chain A

Receptor sequence
>6yb8A (length=419) Species: 9606 (Homo sapiens) [Search protein sequence]
LNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAI
SNKITSCIFQLLQEAGIKTAFTRKCGETAFIAPQCEMIPIEWVCRRIATG
SFLKRNPGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKFCFAGLL
IGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLA
DVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVAERV
ELLLKSESQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGP
DETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPLTPD
WGVQDVWSSLRLPSGLGCSTVLSPEGSAQFAAQIFGLSNHLVWSKLRASI
LNTWISLKQADKKIRECNL
3D structure
PDB6yb8 Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.
ChainA
Resolution2.36 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.21: phosphoribosylaminoimidazole carboxylase.
6.3.2.6: phosphoribosylaminoimidazolesuccinocarboxamide synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C2R A S274 D277 S301 A302 H303 A329 G330 S332 G334 S268 D271 S295 A296 H297 A323 G324 S326 G328
BS02 OK8 A A41 G42 R101 G106 S107 D189 K191 D212 W214 R215 K228 R232 A35 G36 R95 G100 S101 D183 K185 D206 W208 R209 K222 R226
BS03 IMD A E97 F129 E91 F123
Gene Ontology
Molecular Function
GO:0004638 phosphoribosylaminoimidazole carboxylase activity
GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016831 carboxy-lyase activity
GO:0016874 ligase activity
GO:0042802 identical protein binding
GO:0045296 cadherin binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006177 GMP biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0009113 purine nucleobase biosynthetic process
GO:0044208 'de novo' AMP biosynthetic process
GO:0097294 'de novo' XMP biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6yb8, PDBe:6yb8, PDBj:6yb8
PDBsum6yb8
PubMed32571877
UniProtP22234|PUR6_HUMAN Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (Gene Name=PAICS)

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