Structure of PDB 6ya8 Chain A

Receptor sequence
>6ya8A (length=340) Species: 9606 (Homo sapiens) [Search protein sequence]
AGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKI
ALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYL
EHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNR
RLKKYALVDFGLAQGTHDTKIELLKFVPASLTCDCYATDKVCSICLSRRQ
QVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKAS
DDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGA
GGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDM
3D structure
PDB6ya8 Structural Basis for the Activation and Target Site Specificity of CDC7 Kinase.
ChainA
Resolution1.79 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D177 K179 N182 D196 T376
Catalytic site (residue number reindexed from 1) D140 K142 N145 D159 T208
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A S70 V72 A88 K90 M134 Y136 L137 H139 S181 L184 D196 S33 V35 A51 K53 M97 Y99 L100 H102 S144 L147 D159
BS02 MG A N182 D196 N145 D159
BS03 BEF A D177 K179 N182 D196 D140 K142 N145 D159
BS04 ZN A C351 C353 C360 C363 C183 C185 C192 C195
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6ya8, PDBe:6ya8, PDBj:6ya8
PDBsum6ya8
PubMed32521228
UniProtO00311|CDC7_HUMAN Cell division cycle 7-related protein kinase (Gene Name=CDC7)

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