Structure of PDB 6ya7 Chain A

Receptor sequence

>6ya7A (length=350) Species: 9606 (Homo sapiens)

GVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIA
LKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLE
HESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRR
LKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERPASLTCDCYATDKVCS
ICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGR
YPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKL
CERLRGAGAGGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMS

3D structure

• PDB: 6ya7 Structural Basis for the Activation and Target Site Specificity of CDC7 Kinase.
• Chain: A
• Resolution: 1.67 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D177 K179 N182 D196 T376
• Catalytic site (residue number reindexed from 1): D139 K141 N144 D158 T215
• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	T68 F69 S96 R100 D177 K179 N182 D196 G198 L199 Q201 V214 R373 A374 G375 T376 R380 Y412	T30 F31 S58 R62 D139 K141 N144 D158 G160 L161 Q163 V176 R212 A213 G214 T215 R219 Y251
BS02	ZN	A	C351 C353 C360 C363	C190 C192 C199 C202
BS03	ZN	A	N182 D196	N144 D158
BS04	ADP	A	G67 S70 V72 A88 K90 M118 P135 Y136 L137 H139 S181 L184 D196	G29 S32 V34 A50 K52 M80 P97 Y98 L99 H101 S143 L146 D158

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:6ya7, PDBe:6ya7, PDBj:6ya7
• PDBsum: 6ya7
• PubMed: 32521228
• UniProt: O00311|CDC7_HUMAN Cell division cycle 7-related protein kinase (Gene Name=CDC7)