Structure of PDB 6y74 Chain A

Receptor sequence
>6y74A (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
DQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQ
LPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPG
SEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEEN
SAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPC
AQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVI
EASFPAGV
3D structure
PDB6y74 Biophysical Characterization of Cancer-Related Carbonic Anhydrase IX
ChainA
Resolution1.53 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H200 H226 H228 E238 H251 T332
Catalytic site (residue number reindexed from 1) H64 H90 H92 E102 H115 T196
Enzyme Commision number 4.2.1.1: carbonic anhydrase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H226 H228 H251 H90 H92 H115
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:6y74, PDBe:6y74, PDBj:6y74
PDBsum6y74
PubMed
UniProtQ16790|CAH9_HUMAN Carbonic anhydrase 9 (Gene Name=CA9)

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