Structure of PDB 6y5p Chain A

Receptor sequence
>6y5pA (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
KSKNPEDVVRRYMQKVKNPPDEDCTICMERLVTASGYEGVLRHKGVRPEL
VGRLGRCGHMYHLLCLVAMYSNGNKDGSLQCPTCKAIYGEKTGTQPPGKM
EFHLIPHSLPGFPDTQTIRIVYDIPTGIQGPEHPNPGKKFTARGFPRHCY
LPNNEKGRKVLRLLITAWERRLIFTIGTSNTTGESDTVVWNEIHHKTEFG
SNLTGHGYPDASYLDNVLAELTAQGVSE
3D structure
PDB6y5p Structural insights into ADP-ribosylation of ubiquitin by Deltex family E3 ubiquitin ligases.
ChainA
Resolution1.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A R530 R534 S566 N567 T568 V576 W577 H581 T584 H593 R143 R147 S179 N180 T181 V189 W190 H194 T197 H206
BS02 ZN A C411 C414 H449 C452 C24 C27 H62 C65
BS03 ZN A C444 H446 C468 C471 C57 H59 C81 C84
Gene Ontology
Molecular Function
GO:0046872 metal ion binding
Biological Process
GO:0007219 Notch signaling pathway
GO:0016567 protein ubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:6y5p, PDBe:6y5p, PDBj:6y5p
PDBsum6y5p
PubMed32948590
UniProtQ86Y01|DTX1_HUMAN E3 ubiquitin-protein ligase DTX1 (Gene Name=DTX1)

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