Structure of PDB 6y5a Chain A

Receptor sequence
>6y5aA (length=388) Species: 10090 (Mus musculus) [Search protein sequence]
TQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQV
LTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVG
KSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWL
HTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSY
AEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKIT
LLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRL
VHKQDLQRPVPDWLRHLVLDRIAWILGLLQELSSIRHFLEKRDEMREVAR
DWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHSS
3D structure
PDB6y5a Asymmetric opening of the homopentameric 5-HT 3A serotonin receptor in lipid bilayers.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SRO A W63 Y64 Y126 K127 W56 Y57 Y119 K120 BindingDB: Ki=361nM,EC50=3400nM
BS02 SRO A W156 Y207 W149 Y200 BindingDB: Ki=361nM,EC50=3400nM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0015276 ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0045211 postsynaptic membrane

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Cellular Component
External links
PDB RCSB:6y5a, PDBe:6y5a, PDBj:6y5a
PDBsum6y5a
PubMed33594077
UniProtP23979|5HT3A_MOUSE 5-hydroxytryptamine receptor 3A (Gene Name=Htr3a)

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