Structure of PDB 6y3z Chain A

Receptor sequence
>6y3zA (length=243) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
SVDRILEDLLVRFIINCPNERELFHFEEASWFYTDFIKLMNPTLPSLKIK
SFAQLIIKLCPLVWKWDIRVDEALQQFSKYKKSIPVRGAAIFNENLSKIL
LVQGTESDSWSFPRGSKDENDIDCCIREVKEEIGFDLTDYIDDNQFIERN
IQGKNYKIFLISGVSEVFNFKPQVRNEIDKIEWFDFKKISKTMYNIKYYL
INSMMRPLSMWLRHQRQIKNEDQLKSYAEEQLKLLLGITKEEQ
3D structure
PDB6y3z Pby1 is a direct partner of the Dcp2 decapping enzyme.
ChainA
Resolution3.49 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.62: 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R17 D21 I28 R4 D8 I15
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0140933 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA

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Molecular Function
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Biological Process
External links
PDB RCSB:6y3z, PDBe:6y3z, PDBj:6y3z
PDBsum6y3z
PubMed32396195
UniProtP53550|DCP2_YEAST m7GpppN-mRNA hydrolase (Gene Name=DCP2)

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