Structure of PDB 6y2x Chain A

Receptor sequence
>6y2xA (length=231) Species: 9606 (Homo sapiens) [Search protein sequence]
PEPEQVIKNYTEELKVPPDEDCIICMEKLSTASGYSDVTDSKAIGSLAVG
HLTKCSHAFHLLCLLAMYNGNKDGSLQCPSCKTIYGEKTGTQPQGKMEVL
RFQMSLPGHEDCGTILIVYSIPHGIQGPEHPNPGKPFTARGFPRQCYLPD
NAQGRKVLELLKVAWKRRLIFTVGTSSTTGETDTVVWNEIHHKTEMDRNI
TGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ
3D structure
PDB6y2x DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination.
ChainA
Resolution1.77 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C412 C415 H450 C453 C22 C25 H60 C63
BS02 ZN A C445 H447 C469 C472 C55 H57 C78 C81
Gene Ontology
Molecular Function
GO:0046872 metal ion binding
Biological Process
GO:0007219 Notch signaling pathway
GO:0016567 protein ubiquitination

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6y2x, PDBe:6y2x, PDBj:6y2x
PDBsum6y2x
PubMed32937373
UniProtQ86UW9|DTX2_HUMAN Probable E3 ubiquitin-protein ligase DTX2 (Gene Name=DTX2)

[Back to BioLiP]