Structure of PDB 6y2v Chain A

Receptor sequence
>6y2vA (length=153) Species: 9606 (Homo sapiens) [Search protein sequence]
TKSVLFVCRGNKCRSPIAEAVFRKLVTDQNISENWVIDSGAVSDWNVGRS
PDPRAVSCLRNHGIHTAHKARQITKEDFATFDYILCMDESNLRDLNRKSN
QVKTCKAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLE
KAH
3D structure
PDB6y2v Computational and structure-guided design of phosphoinositide substrate specificity into the tyrosine specific LMW-PTP enzyme.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.2: acid phosphatase.
3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 A C12 R13 K16 C17 R18 D129 C8 R9 K12 C13 R14 D125
Gene Ontology
Molecular Function
GO:0003993 acid phosphatase activity
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009898 cytoplasmic side of plasma membrane
GO:0042383 sarcolemma
GO:0070062 extracellular exosome

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Molecular Function
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Cellular Component
External links
PDB RCSB:6y2v, PDBe:6y2v, PDBj:6y2v
PDBsum6y2v
PubMed32584877
UniProtP24666|PPAC_HUMAN Low molecular weight phosphotyrosine protein phosphatase (Gene Name=ACP1)

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