Structure of PDB 6xyu Chain A

Receptor sequence
>6xyuA (length=537) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
DRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEP
WHGVLDATGLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPA
TTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFG
FLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFG
ESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKAL
INDCNCNASMLKTNPAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTI
DGAFLPADPMTLMKTADLKDYDILMGNVRDEGTYFLLYDFIDYFDKDDAT
ALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWEGNPGYQNQQQIGRAVG
DHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLHGDEIEY
FFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDGEEWPNFSKED
PVYYIFSTDDKIEKLARGPLAARCSFWNDYLPKVRSW
3D structure
PDB6xyu A Second Look at the Crystal Structures ofDrosophila melanogasterAcetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides.
ChainA
Resolution2.51 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G150 G151 S238 A239 E367 H480
Catalytic site (residue number reindexed from 1) G114 G115 S202 A203 E331 H444
Enzyme Commision number 3.1.1.7: acetylcholinesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I40 A Y71 W83 G150 G151 F330 Y370 W472 Y69 W81 G114 G115 F294 Y334 W436
Gene Ontology
Molecular Function
GO:0003990 acetylcholinesterase activity
GO:0004104 cholinesterase activity
GO:0008233 peptidase activity
GO:0017171 serine hydrolase activity
GO:0042803 protein homodimerization activity
GO:0043199 sulfate binding
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0001507 acetylcholine catabolic process in synaptic cleft
GO:0006581 acetylcholine catabolic process
GO:0007268 chemical synaptic transmission
GO:0019695 choline metabolic process
GO:0042426 choline catabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0043083 synaptic cleft
GO:0045202 synapse
GO:0098552 side of membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xyu, PDBe:6xyu, PDBj:6xyu
PDBsum6xyu
PubMed32155891
UniProtP07140|ACES_DROME Acetylcholinesterase (Gene Name=Ace)

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