Structure of PDB 6xxm Chain A

Receptor sequence
>6xxmA (length=356) Species: 9606 (Homo sapiens) [Search protein sequence]
EAPAGALAAVLKHSSTLPPESTQVRGYDFNRGVNYRALLEAFGTTGFQAT
NFGRAVQQVNAMIEKKLEPLSQDEDQHADLTQSRRPLTSCTIFLGYTSNL
ISSGIRETIRYLVQHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKE
LRENGINRIGNLLVPNENYCKFEDWLMPILDQMVMEQNTEGVKWTPSKMI
ARLGKEINNPESVYYWAQKNHIPVFSPALTDGSLGDMIFFHSYKNPGLVL
DIVEDLRLINTQAIFAKCTGMIILGGGVVKHHIANANLMRNGADYAVYIN
TAQEFDGSDSGARPDEAVSWGKIRVDAQPVKVYADASLVFPLLVAETFAQ
KMDAFM
3D structure
PDB6xxm Half Way to Hypusine-Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase.
ChainA
Resolution1.67 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.46: deoxyhypusine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PUT A E136 E137 S240 D243 E129 E130 S233 D236
BS02 PUT A N292 W327 N285 W320
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0034038 deoxyhypusine synthase activity
GO:0042802 identical protein binding
Biological Process
GO:0006412 translation
GO:0008216 spermidine metabolic process
GO:0008284 positive regulation of cell population proliferation
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine
GO:0042102 positive regulation of T cell proliferation
GO:0042593 glucose homeostasis
GO:0046203 spermidine catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xxm, PDBe:6xxm, PDBj:6xxm
PDBsum6xxm
PubMed32235505
UniProtP49366|DHYS_HUMAN Deoxyhypusine synthase (Gene Name=DHPS)

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