Structure of PDB 6xxi Chain A

Receptor sequence
>6xxiA (length=330) Species: 9606 (Homo sapiens) [Search protein sequence]
STQVRGYDFNRGVNYRALLEAFGTTGFQATNFGRAVQQVNAMIEKKLEPL
HADLTQSRRPLTSCTIFLGYTSNLISSGIRETIRYLVQHNMVDVLVTTAG
GVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNENYCKFEDWL
MPILDQMVMEQNTEGVKWTPSKMIARLGKEINNPESVYYWAQKNHIPVFS
PALTDGSLGDMIFFHSYKNPGLVLDIVEDLRLINTQAIFAKCTGMIILGG
GVVKHHIANANLMRNGADYAVYINTAQEFDGSDSGARPDEAVSWGKIRVD
AQPVKVYADASLVFPLLVAETFAQKMDAFM
3D structure
PDB6xxi Half Way to Hypusine-Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase.
ChainA
Resolution1.679 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.46: deoxyhypusine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A T104 S105 N106 T131 A132 G133 D238 G282 G283 N307 T308 A309 D342 A343 T71 S72 N73 T98 A99 G100 D205 G249 G250 N274 T275 A276 D309 A310
BS02 NAD A G284 H288 D313 S315 S317 G251 H255 D280 S282 S284
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0034038 deoxyhypusine synthase activity
GO:0042802 identical protein binding
Biological Process
GO:0006412 translation
GO:0008216 spermidine metabolic process
GO:0008284 positive regulation of cell population proliferation
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine
GO:0042102 positive regulation of T cell proliferation
GO:0042593 glucose homeostasis
GO:0046203 spermidine catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xxi, PDBe:6xxi, PDBj:6xxi
PDBsum6xxi
PubMed32235505
UniProtP49366|DHYS_HUMAN Deoxyhypusine synthase (Gene Name=DHPS)

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