Structure of PDB 6xup Chain A

Receptor sequence

>6xupA (length=402) Species: 2234 (Archaeoglobus fulgidus) [Search protein sequence]

GLTYRIGNGASVPISNTGELIKGLRNYGPYEVPSLKYNQIALIHNNQFSS
LINQLKSQISSKIDEVWHIHNINISEFIYDSPHFDSIKSQVDNAIDTGVD
GIMLVLPEYNTPLYYKLKSYLINSIPSQFMRYDILSNRNLTFYVDNLLVQ
FVSKLGGKPWILNVDPEKGSDIIIGTGATRIDNVNLFCFAMVFKKDGTML
WNEISPIVTSSEYLTYLKSTIKKVVYGFKKSNPDWDVEKLTLHVSGKRPK
MKDGETKILKETVEELKKQEMVSRDVKYAILHLNETHPFWVMPYEGTKVK
LSSKRYLLTLLQPMVTPIKPLSVEIVSDNWTSEEYYHNVHEILDEIYYLS
KMNWRGFRSRNLPVTVNYPKLVAGIIANVNRYGGYPINPEGNRSLQTNPW
FL

3D structure

PDB

6xup Archaeoglobus fulgidus Argonaute protein with DNA oligoduplex 5'-pATCGTGGCCACGAT

Chain

Resolution

1.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	Y118 T120 Y123 K127 Q137 F138 M139 R140 I143 Y152 N155 Q159 K163 Q329 R380 R385 L427	Y109 T111 Y114 K118 Q128 F129 M130 R131 I134 Y143 N146 Q150 K154 Q312 R355 R360 L402
BS02	dna	A	T26 G27 I30 N148 F151 D154 R383	T17 G18 I21 N139 F142 D145 R358
BS03	MG	A	Q159 L427	Q150 L402
BS04	MG	A	N132 I412 N413	N123 I387 N388

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0046872	metal ion binding

View graph for
Molecular Function

External links

PDB	RCSB:6xup, PDBe:6xup, PDBj:6xup
PDBsum	6xup
PubMed
UniProt	O28951\|PIWI_ARCFU Piwi protein (Gene Name=AF_1318)

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