Structure of PDB 6xu2 Chain A

Receptor sequence
>6xu2A (length=1091) Species: 9606 (Homo sapiens) [Search protein sequence]
AAAAEQQQFYLLLGNLLSPDNVVRKQAEETYENIPGQSKITFLLQAIRNT
TAAEEARQMAAVLLRRLLSSAFDEVYPALPSDVQTAIKSELLMIIQMETQ
SSMRKKVCDIAAELARNLIDEDGNNQWPEGLKFLFDSVSSQNVGLREAAL
HIFWNFPGIFGNQQQHYLDVIKRMLVQCMQDQEHPSIRTLSARATAAFIL
ANEHNVALFKHFADLLPGFLQAVNDSCYQNDDSVLKSLVEIADTVPKYLR
PHLEATLQLSLKLCGDTSLNNMQRQLALEVIVTLSETAAAMLRKHTNIVA
QTIPQMLAMMVDLEEDEDWANADELFDSNAVAGESALDRMACGLGGKLVL
PMIKEHIMQMLQNPDWKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLL
FLQDPHPRVRYAACNAVGQMATDFAPGFQKKFHEKVIAALLQTMEDQGNQ
RVQAHAAAALINFTEDCPKSLLIPYLDNLVKHLHSIMVLKLQELIQKGTK
LVLEQVVTSIASVADTAEEKFVPYYDLFMPSLKHIVENAVQKELRLLRGK
TIECISLIGLAVGKEKFMQDASDVMQLLLKTQTDFNDMEDDDPQISYMIS
AWARMCKILGKEFQQYLPVVMGPLMKTASIKPEVALLDTQDMENMSDDDG
WEFVNLGDQQSFGIKTAGLEEKSTACQMLVCYAKELKEGFVEYTEQVVKL
MVPLLKFYFHDGVRVAAAESMPLLLECARVRGPEYLTQMWHFMCDALIKA
IGTEPDSDVLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFK
NQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSDILHSIFSSYKEK
VLPWFEQLLPLIVNLICPHRPWPDRQWGLCIFDDVIEHCSPASFKYAEYF
LRPMLQYVCDNSPEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQ
SADSKTKENVNATENCISAVGKIMKFKPDCVNVEEVLPHWLSWLPLHEDK
EEAVQTFNYLCDLIESNHPIVLGPNNTNLPKIFSIIAEGEMHEAIKHEDP
CAKRLANVVRQVQTSGGLWTECIAQLSPEQQAAIQELLNSA
3D structure
PDB6xu2 X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking.
ChainA
Resolution2.834 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y855 K859 Q900 W901 C904 Q941 Y945 N989 D1023 Y831 K835 Q876 W877 C880 Q917 Y921 N965 D999
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005095 GTPase inhibitor activity
GO:0005515 protein binding
GO:0008139 nuclear localization sequence binding
GO:0031267 small GTPase binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0002753 cytoplasmic pattern recognition receptor signaling pathway
GO:0006606 protein import into nucleus
GO:0006607 NLS-bearing protein import into nucleus
GO:0006610 ribosomal protein import into nucleus
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0042307 positive regulation of protein import into nucleus
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0071230 cellular response to amino acid stimulus
Cellular Component
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016020 membrane
GO:0031965 nuclear membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xu2, PDBe:6xu2, PDBj:6xu2
PDBsum6xu2
PubMed32222384
UniProtO00410|IPO5_HUMAN Importin-5 (Gene Name=IPO5)

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