Structure of PDB 6xte Chain A

Receptor sequence
>6xteA (length=1075) Species: 9606 (Homo sapiens) [Search protein sequence]
AMAAAEQQQFYLLLGNLLSPDNVVRKQAEETYENIPGQSKITFLLQAIRN
TTAAEEARQMAAVLLRRLLSSAFDEVYPALPSDVQTAIKSELLMIIQMET
QSSMRKKVCDIAAELARNLIDEDGNNQWPEGLKFLFDSVSSQNVGLREAA
LHIFWNFPGIFGNQQQHYLDVIKRMLVQCMQDQEHPSIRTLSARATAAFI
LANEHNVALFKHFADLLPGFLQAVNDSCYQNDDSVLKSLVEIADTVPKYL
RPHLEATLQLSLKLCGDTSLNNMQRQLALEVIVTLSETAAAMLRKHTNIV
AQTIPQMLAMMVDLEDFDSNAVAGESALDRMACGLGGKLVLPMIKEHIMQ
MLQNPDWKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRV
RYAACNAVGQMATDFAPGFQKKFHEKVIAALLQTMEDQGNQRVQAHAAAA
LINFTEDCPKSLLIPYLDNLVKHLHSIMVLKLQELIQKGTKLVLEQVVTS
IASVADTAEEKFVPYYDLFMPSLKHIVENAVQKELRLLRGKTIECISLIG
LAVGKEKFMQDASDVMQLLLKTQTDFPQISYMISAWARMCKILGKEFQQY
LPVVMGPLMKTASIKPEVALLDTQDMENMSDDDGWEFVNLGDQQSFGIKT
AGLEEKSTACQMLVCYAKELKEGFVEYTEQVVKLMVPLLKFYFHDGVRVA
AAESMPLLLECARVRGPEYLTQMWHFMCDALIKAIGTEPDSDVLSEIMHS
FAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDE
QVEESLQDEDDNDVYILTKVSDILHSIFSSYKEKVLPWFEQLLPLIVNLI
CPHRPWPDRQWGLCIFDDVIEHCSPASFKYAEYFLRPMLQYVCDNSPEVR
QAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSKTKENVNATENC
ISAVGKIMKFKPDCVNVEEVLPHWLSWLPLHEDKEEAVQTFNYLCDLIES
NHPIVLGPNNTNLPKIFSIIAEGEMHEAIKHEDPCAKRLANVVRQVQTSG
GLWTECIAQLSPEQQAAIQELLNSA
3D structure
PDB6xte X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking.
ChainA
Resolution2.27 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y855 K859 W901 Q941 A942 Y945 N989 D1023 E1026 Y815 K819 W861 Q901 A902 Y905 N949 D983 E986
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005095 GTPase inhibitor activity
GO:0005515 protein binding
GO:0008139 nuclear localization sequence binding
GO:0031267 small GTPase binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0002753 cytoplasmic pattern recognition receptor signaling pathway
GO:0006606 protein import into nucleus
GO:0006607 NLS-bearing protein import into nucleus
GO:0006610 ribosomal protein import into nucleus
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0042307 positive regulation of protein import into nucleus
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0071230 cellular response to amino acid stimulus
Cellular Component
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016020 membrane
GO:0031965 nuclear membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xte, PDBe:6xte, PDBj:6xte
PDBsum6xte
PubMed32222384
UniProtO00410|IPO5_HUMAN Importin-5 (Gene Name=IPO5)

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