Structure of PDB 6xs9 Chain A

Receptor sequence
>6xs9A (length=184) Species: 9606 (Homo sapiens) [Search protein sequence]
DRMLVLVLGDLHIPHRCNSLPAKFKKLLVPGKIQHILCTGNLCTKESYDY
LKTLAGDVHIVRGDFDENLNYPEQKVVTVGQFKIGLIHGHQVIPWGDMAS
LALLQRQFDVDILISGHTHKFEAFEHENKFYINPGSATGAYNALETNIIP
SFVLMDIQASTVVTYVYQLIGDDVKVERIEYKKP
3D structure
PDB6xs9 De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex.
ChainA
Resolution2.69 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L2 L25 K30 Y163 Y165 Q166 V172 K173 V174 L4 L27 K32 Y165 Y167 Q168 V174 K175 V176
BS02 peptide A Q72 L102 Q105 F106 Q74 L104 Q107 F108
BS03 peptide A Q89 I91 S98 L101 Q91 I93 S100 L103
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006886 intracellular protein transport
GO:0010506 regulation of autophagy
GO:0015031 protein transport
GO:0032456 endocytic recycling
GO:0042147 retrograde transport, endosome to Golgi
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005829 cytosol
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0030904 retromer complex
GO:0030906 retromer, cargo-selective complex
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xs9, PDBe:6xs9, PDBj:6xs9
PDBsum6xs9
PubMed34851660
UniProtQ9UBQ0|VPS29_HUMAN Vacuolar protein sorting-associated protein 29 (Gene Name=VPS29)

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