Structure of PDB 6xrp Chain A

Receptor sequence
>6xrpA (length=180) Species: 562 (Escherichia coli) [Search protein sequence]
RAGPVTWVMMIACVVVFIAMQILGDQEVMLWLAWPFDPTLKFEFWRYFTH
ALMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLISALLSGYVQQK
FSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAGW
FDLFGMSMANGAHIAGLAVGLAMAFVDSLN
3D structure
PDB6xrp Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.105: rhomboid protease.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F146 H150 S193 W196 F197 G198 G199 S201 M247 S248 M249 A250 F55 H59 S102 W105 F106 G107 G108 S110 M156 S157 M158 A159
BS02 V87 A M149 H150 F153 N154 S201 F245 M247 M249 H254 M58 H59 F62 N63 S110 F154 M156 M158 H163
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xrp, PDBe:6xrp, PDBj:6xrp
PDBsum6xrp
PubMed32888502
UniProtP09391|GLPG_ECOLI Rhomboid protease GlpG (Gene Name=glpG)

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