Structure of PDB 6xp9 Chain A

Receptor sequence
>6xp9A (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVWSQVRKDLKVSLQL
RGEDGSVWNYKPPIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQ
ISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDLLEPMLKFHYML
KKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECN
RPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFG
ISLTERHKILHRLLQE
3D structure
PDB6xp9 Structure-based amelioration of PXR transactivation in a novel series of macrocyclic allosteric inhibitors of HIV-1 integrase.
ChainA
Resolution2.27 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QCG A V211 L213 L239 M243 M246 Q285 F288 W299 Y306 V46 L48 L67 M71 M74 Q113 F116 W127 Y134
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6xp9, PDBe:6xp9, PDBj:6xp9
PDBsum6xp9
PubMed32890685
UniProtO75469|NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Gene Name=NR1I2);
Q15788

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