Structure of PDB 6xov Chain A

Receptor sequence

>6xovA (length=966) Species: 9606 (Homo sapiens)

AACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAR
EDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSL
STFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEG
WRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTY
SVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIH
EEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTVSVS
FLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYN
GYTREAYFSVGLQGIVEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHK
IEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQEN
PKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSP
GDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAG
DIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLD
YREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMM
QLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLT
PAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCS
VNATPQQMPQTEKAVEDFLRSIGRSTFKPWQMKTHFLMPFPVNYVGECIR
TVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLY
SYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSD
KGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAIL
GPENPKIAKDPSWIIR

3D structure

• PDB: 6xov Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition.
• Chain: A
• Resolution: 3.3 Å

Enzymatic activity

• Enzyme Commision number: 3.4.24.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	E107 H108 L111 N136 A137 F138 R900 Y906	E76 H77 L80 N105 A106 F107 R829 Y835
BS02	peptide	A	I432 Y450 L467	I401 Y419 L436

Gene Ontology

Molecular Function

• GO:0004222 metalloendopeptidase activity
• GO:0008047 enzyme activator activity
• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0006626 protein targeting to mitochondrion
• GO:0016485 protein processing

Cellular Component

• GO:0005739 mitochondrion
• GO:0005759 mitochondrial matrix

External links

• PDB: RCSB:6xov, PDBe:6xov, PDBj:6xov
• PDBsum: 6xov
• PubMed: 35383169
• UniProt: Q5JRX3|PREP_HUMAN Presequence protease, mitochondrial (Gene Name=PITRM1)