Structure of PDB 6xn8 Chain A

Receptor sequence

>6xn8A (length=540) Species: 1380357 (Rhodospirillales bacterium URHD0017) [Search protein sequence]

SSEVDGATLIARSLKQQGIDHLFGVVGFPITAIAAAAQKEGVAYLGMRNE
QSAAYAAAAYGYLTGRPGAAVVVTGPGVVHGLSGLANAQQNCWPMILIGG
ASETYRGGMGAFQEERQVLIASPFCKFAHGIESVARIPFYVEMATRNAIY
GRPGATYLDMPDDIIRGTCETDKIAQAERVPEAPRSVAPAENVEAALDLL
EKAQRPLVLLGKGMAWSRGEDEVRAFIERTQVPFVRSPMGKGVMPDDHPL
SASAARTLALQQADVIFLMGARLNWIFHFGLPPRYAKDVKVIQLDIAPEE
IGHNKPTEVALVGDGKAIMAQLNKALVNRQWFHPKDTPWRQALTKKAAEN
VATIKPQVDDDQGPAGYYRALRDVAAWMPKNAILSAEGAGTMDIGLTQLA
SSNARSVLNAGTYGTMGVGLGQAIAAAVSDPSRPVIHLSGDSAIGFSGME
METLVRYNLPVKIVVLNNGGIGPGMPEIPENPMFNLKPNALIYGARYDKV
MEAFGGKGIFVKEPKDIRKALDEAMAFKGPALVNVVLSQG

3D structure

PDB

6xn8 Crystal Structure of 2-hydroxyacyl CoA lyase (HACL) from Rhodospirillales bacterium URHD0017

Chain

Resolution

1.95 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	V25 G27 F28 P29 I30 E50 V73 F112 Q113 E114 D162 F277 G388 G414 M416 D441 N468 G470 I471 P473 G474 E477
Catalytic site (residue number reindexed from 1)	V25 G27 F28 P29 I30 E50 V73 F112 Q113 E114 D162 F277 G388 G414 M416 D441 N468 G470 I471 P473 G474 E477
Enzyme Commision number	?

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	MG	A	D441 N468 G470	D441 N468 G470
BS02	TZD	A	Y367 A389 G390 T391 G414 M416 G440 D441 S442 A443 F446 N468 G470 I471 G472	Y367 A389 G390 T391 G414 M416 G440 D441 S442 A443 F446 N468 G470 I471 G472
BS03	ADP	A	R152 G211 K212 S237 G270 R272 D295 I296 G313 D314 G315	R152 G211 K212 S237 G270 R272 D295 I296 G313 D314 G315
BS04	TZD	A	E50 V73 P76 H80	E50 V73 P76 H80

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0016829	lyase activity
GO:0030976	thiamine pyrophosphate binding
GO:0046872	metal ion binding

	Biological Process
GO:0001561	fatty acid alpha-oxidation
GO:0019752	carboxylic acid metabolic process

	Cellular Component
GO:0005777	peroxisome

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6xn8, PDBe:6xn8, PDBj:6xn8
PDBsum	6xn8
PubMed
UniProt	A0A1H8YFL8

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