Structure of PDB 6xmq Chain A

Receptor sequence
>6xmqA (length=1085) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
KSFVSSPIVRDSTLLVPKSLIAKPYVLPFFPLYATFAQLYFEWTFVYLGT
LVSLNILVMLMPAWNVKIKAKFNYSTTKNVNEATHILIYTTPNNGSDGIV
EIQRVTEAGSLQTFFQFQKKRFLWHENEQVFSSPKFLVDESPKIGDFQKC
KGHSGDLTHLKRLYGENSFDIPIPTFMELFKEHAVAPLFVFQVFCVALWL
LDEFWYYSLFNLFMIISMEAAAVFQRLTALKEFRTMGIKPYTINVFRNKK
WVALQTNELLPMDLVSITRTAEESAIPCDLILLDGSAIVNEAMLSGESTP
LLKESIKLRPSEDNLQLDGVDKIAVLHGGTKALQVTPPEHKSDIPPPPDG
GALAIVTKTGFETSQGSLVRVMIYSAERVSVDNKEALMFILFLLIFAVIA
SWYVWVEGTKMGRIQSKLILDCILIITSVVPPELPMELTMAVNSSLAALA
KFYVYCTEPFRIPFAGRIDVCCFDKTGTLTGEDLVFEGLAGISADSENIR
HLYSAAEAPESTILVIGAAHALVKLEDGDIVGDPMEKATLKAVGWAVERK
NSNYREGTGKLDIIRRFQFSSALKRSASIASHNDALFAAVKGAPETIRER
LSDIPKNYDEIYKSFTRSGSRVLALASKSLPKDLNRDDVESELTFNGFLI
FHCPLKDDAIETIKMLNESSHRSIMITGDNPLTAVHVAKEVGIVFGETLI
LDRAGKSDDNQLLFRDVEETVSIPFDPSKDTFDHSKLFDRYDIAVTGYAL
NALEGHSQLRDLLRHTWVYARVSPSQKEFLLNTLKDMGYQTLMCGDGTND
VGALKQAHVGIALLNGTEEGLKKLGEQRRLEASCAAPFTSKLANVSAVTN
IIRQGRCALVNTIQMYKILALNCLISAYSLSIIYMAGVKFGDGQATVSGL
LLSVCFLSISRGKPLEKLSKQRPQSGIFNVYIMGSILSQFAVHIATLVYI
TTEIYKLEPREPQVDLEKEFAPSLLNTGIFIIQLVQQVSTFAVNYQGEPF
RENIRSNKGMYYGLLGVTGLALASATEFLPELNEAMKFVPMTDDFKIKLT
LTLLLDFFGSWGVEHFFKFFFMDDKPSDISVQQVK
3D structure
PDB6xmq The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase.
ChainA
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP A D487 T489 F582 K604 G605 R634 L636 D699 D816 N819 D474 T476 F569 K591 G592 R621 L623 D679 D796 N799
BS02 MG A D487 T489 D816 D474 T476 D796
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015662 P-type ion transporter activity
GO:0016887 ATP hydrolysis activity
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity
GO:0046872 metal ion binding
GO:0070273 phosphatidylinositol-4-phosphate binding
GO:0140358 P-type transmembrane transporter activity
GO:0140567 membrane protein dislocase activity
Biological Process
GO:0006874 intracellular calcium ion homeostasis
GO:0015031 protein transport
GO:0030026 intracellular manganese ion homeostasis
GO:0034214 protein hexamerization
GO:0043335 protein unfolding
GO:0055085 transmembrane transport
GO:0055092 sterol homeostasis
GO:0098655 monoatomic cation transmembrane transport
GO:0140569 extraction of mislocalized protein from ER membrane
Cellular Component
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005801 cis-Golgi network
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xmq, PDBe:6xmq, PDBj:6xmq
PDBsum6xmq
PubMed32973005
UniProtP39986|SPF1_YEAST Endoplasmic reticulum transmembrane helix translocase (Gene Name=SPF1)

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