Structure of PDB 6xmf Chain A

Receptor sequence

>6xmfA (length=627) Species: 256318 (metagenome) [Search protein sequence]

PRPRYREERTLVRKLLPRPGQSKQEFRENVKKLRKAFLQFNADVSGVCQW
AIQFRPRYGKPAEPTETFWKFFLEPETSLPPNDSRSPEFRRLQAFEAAAG
INGAAALDDPAFTNELRDSILAVASRPKTKEAQRLFSRLKDYQPAHRMIL
AKVAAEWIESRYRRAHQNWERNYEEWKKEKQEWEQNHPELTPEIREAFNQ
IFQQLEVKPAARLLQNKDNCQYAGKNKHSHTALCKQYQQQLSHDELYRKW
RREYWREPRKPVFRYPSVKRHSIAKIFGENYFQADFKNSVVGLRLDSMPA
GQYLEFAFAPWPRNYRPQPGETEISSVHLHFVGTRPRIGFRFRVPHKRSR
FDCTQEELDELRSRTFPRKAQDQKFLEAARKRLLETFPGNAEQELRLLAV
DLGTDSARAAFFIGKTFQQAFPLKIVKIEKLYEQWPQPRPGLSRDHVGRH
LQKMRAQASEIAQKRQELTGTTLQPFDLRGLTVHTARMIRDWARLNARQI
IQLAEENQVDLIVLESLRGFRPPGYENLDQEKKRRVAFFAHGRIRRKVTE
KAVERGMRVVTVPYLASSKVCAECRKKQKDNKQWEKNKKRGLFKCEGCGS
QAQVDENAARVLGRVFWGEIELPTAIP

3D structure

PDB

6xmf Cryo-EM structure of the RNA-guided ribonuclease Cas12g.

Chain

Resolution

3.1 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	R19 R22 T23 L24 V25 R26 K27 P30 Q34 S35 K36 K44 A55 S58 Q62 R68 T142 E144 R147 E219 K221 R368 K372 V374 F375 R376 Y377 P378 S379 K381 P424 N426 Y427 T446 R449 R453 R474 P479 K481 K539 E541 L543 P566 G567 H572 H576 I587 K590 R591 L594 F616 D617 R619 G620 L621 V623 H624 R627 D631 R634 L635 R638 R658 K687 E690	R6 R9 T10 L11 V12 R13 K14 P17 Q21 S22 K23 K31 A42 S45 Q49 R55 T129 E131 R134 E206 K208 R256 K260 V262 F263 R264 Y265 P266 S267 K269 P312 N314 Y315 T334 R337 R341 R362 P367 K369 K427 E429 L431 P440 G441 H446 H450 I461 K464 R465 L468 F476 D477 R479 G480 L481 V483 H484 R487 D491 R494 L495 R498 R518 K547 E550
BS02	ZN	A	C711 C714 C735 C738	C571 C574 C595 C598

External links

PDB	RCSB:6xmf, PDBe:6xmf, PDBj:6xmf
PDBsum	6xmf
PubMed	33495647

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