Structure of PDB 6xlv Chain A

Receptor sequence

>6xlvA (length=203) Species: 9606 (Homo sapiens) [Search protein sequence]

GPLGSQMTRQARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQAPGNPVL
AVQINQDKKFAFLEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPG
MENPSVYVPGVVSTVVPDSAHKLFIGGLPNYLNDDQVKELLTSFGPLKAF
NLVKDSATGLSKGYAFCEYVDINVTDQAIAGLNGMQLGDKKLLVQRASVG
AKN

3D structure

PDB

6xlv Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing.

Chain

Resolution

1.4 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	R146 R150 Y152 N155 F197 F199 K225 R227 R228 P229 H230 D231 T252 V254 K260 F262 G264 G265 N289 Y302 F304 K328 K329 A335 G338 A339 K340	R9 R13 Y15 N18 F60 F62 K88 R90 R91 P92 H93 D94 T114 V116 K122 F124 G126 G127 N151 Y164 F166 K190 K191 A197 G200 A201 K202

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003723	RNA binding

	Biological Process
GO:0006397	mRNA processing

	Cellular Component
GO:0005634	nucleus

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6xlv, PDBe:6xlv, PDBj:6xlv
PDBsum	6xlv
PubMed	33020180
UniProt	P26368\|U2AF2_HUMAN Splicing factor U2AF 65 kDa subunit (Gene Name=U2AF2)

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