Structure of PDB 6xlo Chain A

Receptor sequence
>6xloA (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLPTPQQLQAFKNEV
GVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYKHLHASETKFEMKK
LIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKS
RWSGQLSGSILWMAPEVIRPYSFQSDVYAFGIVLYELMTGQLPYSNINNR
DQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILA
EIEELARE
3D structure
PDB6xlo Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3 H )-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor.
ChainA
Resolution2.493 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 V5J A V471 A481 K483 E501 L505 L514 I527 T529 W531 C532 H574 I592 G593 D594 K601 V23 A33 K35 E49 L53 L62 I75 T77 W79 C80 H122 I140 G141 D142 K149
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6xlo, PDBe:6xlo, PDBj:6xlo
PDBsum6xlo
PubMed33780623
UniProtP15056|BRAF_HUMAN Serine/threonine-protein kinase B-raf (Gene Name=BRAF)

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