Structure of PDB 6xlh Chain A

Receptor sequence
>6xlhA (length=607) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
GETFEFQAEITQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQALSD
PKQLETEPDLFIRITPKPEEKVLEIRDSGIGMTKAELINNLGTIAKSGTK
AFMEALSAGADVSMIGQFGVGFYSLFLVADRVQVISKNNEDEQYIWESNA
GGSFTVTLDEVNERIGRGTVLRLFLKDDQLEYLEEKRIKEVIKRHSEFVA
YPIQLLVTKVQELEELNKTKPLWTRNPSDITQEEYNAFYKSISNDWEDPL
YVKHFSVEGQLEFRAILFIPKRAPFNNIKLYVRRVFITDEAEDLIPEWLS
FVKGVVDSEDLPLNLSREMLQQNKIMKVIRKNIVKKLIEAFNEIAEDSEQ
FDKFYSAFAKNIKLGVHEDTQNRAALAKLLRYNSTKSVDELTSLTDYVTR
MPEHQKNIYYITGESLKAVEKSPFLDALKAKNFEVLFLTDPIDEYAFTQL
KEFEGKTLVDITKDFELEETDEEKAEREKEIKEYEPLTKALKDILGDQVE
KVVVSYKLLDAPAAIRTGQFGWSANMERIMKAQALRSKKTFEISPKSPII
KELKKRVDEGGAQDKTVKDLTNLLFETALLTSGFSLEEPTSFASRINRLI
SLGLNID
3D structure
PDB6xlh Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1
ChainA
Resolution2.83 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS A N37 A41 K44 M84 N92 S99 G100 T101 G118 Q119 F120 G121 G123 F124 T171 R376 N35 A39 K42 M82 N90 S97 G98 T99 G116 Q117 F118 G119 G121 F122 T169 R317
BS02 MG A E33 N37 E31 N35
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0000492 box C/D snoRNP assembly
GO:0000723 telomere maintenance
GO:0006457 protein folding
GO:0034605 cellular response to heat
GO:0043248 proteasome assembly
GO:0050821 protein stabilization
GO:0070482 response to oxygen levels
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0032991 protein-containing complex
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xlh, PDBe:6xlh, PDBj:6xlh
PDBsum6xlh
PubMed
UniProtP15108|HSC82_YEAST ATP-dependent molecular chaperone HSC82 (Gene Name=HSC82)

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