Structure of PDB 6xi8 Chain A
Receptor sequence
>6xi8A (length=290) Species:
559292
(Saccharomyces cerevisiae S288C) [
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EYTKEKKVGEGTYAVVYLGCKIAIKEIKTSKDGLDMSAIREVKYLQEMQH
PNVIELIDIFMAYDNLNLVLEFLPTDLEVVIKDKSILFTPADIKAWMLMT
LRGVYHCHRNFILHRDLKPNNLLFSPDGQIKVADFGLARAIPAPHEILTS
NVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELMLRIPYLPGQNDVDQ
MEVTFRALGTPTDRDWPEVSSFMTYNKLQIYPPPSRDELRKRFIAASEYA
LDFMCGMLTMNPQKRWTAVQCLESDYFKELPPPSDPSSIK
3D structure
PDB
6xi8
Structure of TFIIK for phosphorylation of CTD of RNA polymerase II.
Chain
A
Resolution
3.64 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB)
D129 K131 N134 D147 I160 T167
Catalytic site (residue number reindexed from 1)
D116 K118 N121 D134 I147 T154
Enzyme Commision number
2.7.11.23
: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#
Ligand
Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01
ADP
A
L83 E84 F85 K131 N134 D147
L70 E71 F72 K118 N121 D134
Gene Ontology
Molecular Function
GO:0004672
protein kinase activity
GO:0004674
protein serine/threonine kinase activity
GO:0004693
cyclin-dependent protein serine/threonine kinase activity
GO:0005515
protein binding
GO:0005524
ATP binding
GO:0008353
RNA polymerase II CTD heptapeptide repeat kinase activity
Biological Process
GO:0006289
nucleotide-excision repair
GO:0006355
regulation of DNA-templated transcription
GO:0006360
transcription by RNA polymerase I
GO:0006366
transcription by RNA polymerase II
GO:0006367
transcription initiation at RNA polymerase II promoter
GO:0006370
7-methylguanosine mRNA capping
GO:0006468
protein phosphorylation
GO:0006995
cellular response to nitrogen starvation
GO:0009891
positive regulation of biosynthetic process
GO:0010508
positive regulation of autophagy
GO:0016310
phosphorylation
GO:0032968
positive regulation of transcription elongation by RNA polymerase II
GO:0045944
positive regulation of transcription by RNA polymerase II
GO:0051301
cell division
GO:0051726
regulation of cell cycle
GO:1905866
positive regulation of Atg1/ULK1 kinase complex assembly
Cellular Component
GO:0005634
nucleus
GO:0005675
transcription factor TFIIH holo complex
GO:0005737
cytoplasm
GO:0005829
cytosol
GO:0070985
transcription factor TFIIK complex
GO:1902554
serine/threonine protein kinase complex
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:6xi8
,
PDBe:6xi8
,
PDBj:6xi8
PDBsum
6xi8
PubMed
33827808
UniProt
P06242
|KIN28_YEAST Serine/threonine-protein kinase KIN28 (Gene Name=KIN28)
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