Structure of PDB 6xfs Chain A

Receptor sequence
>6xfsA (length=357) Species: 562 (Escherichia coli) [Search protein sequence]
PQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPV
TQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGI
TLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSS
IGLFGALAVKPSGLSFEQAMKTRVFQPLKLNHTWINVPSAEEKNYAWGYR
EGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKPLDINEKTLQQGIQL
AQSRYWQTGDMYQGLGWEMLDWPVNPDIIINGSDNKIALAARPVKPITPP
TPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNYPNPARVAAAW
QILNALQ
3D structure
PDB6xfs Class C beta-lactamase from Escherichia coli in complex with Tazobactam
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S91 K94 Y177 E299 K342 A345
Catalytic site (residue number reindexed from 1) S60 K63 Y146 E268 K311 A314
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TBE A S91 Q147 Y248 A345 T346 S60 Q116 Y217 A314 T315
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
Biological Process
GO:0017001 antibiotic catabolic process
Cellular Component
GO:0030288 outer membrane-bounded periplasmic space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xfs, PDBe:6xfs, PDBj:6xfs
PDBsum6xfs
PubMed
UniProtP00811|AMPC_ECOLI Beta-lactamase (Gene Name=ampC)

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